How widespread are metabolite-sensing arrest peptides?

Seip, B. & Innis, C.A. (2016). How widespread is metabolite sensing by ribosome-arresting nascent peptides? J Mol Biol. 428, 2217-2227.

In this Perspective, published in a special issue of the Journal of Molecular Biology summarizing the state of the ribosome field after the 2016 Ribosome Structure and Function meeting in Strasbourg, we present the state of the art on known metabolite-sensing arrest peptides, their ligands and their mechanisms of action. Furthermore, we propose that known peptides are probably much more widespread than generally thought and highlight the need for large scale approaches to identify them.