Directed evolution in drops

Manteca, A., Gadea, A., Van Assche, D., Cossard, P., Gillard-Bocquet, M., Beneyton, T., Innis, C.A., Baret, J.C. (2021). Directed Evolution in Drops: Molecular Aspects and Applications. ACS Synth Biol 10, 2772-2783.

This review explores the use of directed evolution and droplet microfluidics in the engineering of functional biomolecules (enzymes, antibodies, aptamers and ribozymes) and underlines their immense combined potential in the discovery and improvement of biomolecules tailored to specific needs.