Could ribosomes help us find new drugs?

Charon, J., Manteca, A., Innis, C.A. (2019). Using the bacterial ribosome as a discovery platform for peptide-based antibiotics. Biochemistry 58, 75-84.

Editorial by Schepartz, A. (2019). Biochemistry 58, 1-6

Ribosomes are known to synthesize antimicrobial peptides which in turn act as potent translation inhibitors. In this perspective, we propose that bacterial ribosome could be used as both a target and a tool for the production and selection of peptide-based antimicrobials.