Antimicrobial development in the cryo-EM era

Herrero Del Valle, A. & Innis, C.A. (2020). Prospects for antimicrobial development in the cryo-EM era – a focus on the ribosome. FEMS Microbiol Rev. 44, 793-803.

Structural biology plays a major role in understanding the mechanism of action of antimicrobials that target the ribosome and hence is an essential tool for the development of new drugs to combat resistant infections. This perspective discusses how cryo-electron microscopy is changing our understanding of the ribosome, an established antimicrobial target, and how methodological developments can help it become an integral part of the antimicrobial drug discovery pipeline.