Two new PrAMPs from the bottlenose dolphin

Mardirossian, M., Pérébaskine, N., Benincasa, M., Gambato, S., Hofmann, S., Huter, P., Müller, C., Hilpert, K., Innis, C.A., Tossi, A., Wilson, D.N. (2018). The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome. Cell Chem Biol. 25, 530-539.

PDB entries: 6FKR

This study identifies two PrAMPs from the bottlenose dolphin, Tur1A and Tur1B, and presents the crystal structure of Tur1A bound within the ribosomal exit tunnel. Tur1A is orthologous to Bac7 and similarly blocks the transition to the elongation stage of protein synthesis. Tur1B on the other hand, is shown to be a poor translation inhibitor, indicating a different mechanism of action.