PrAMPs that do not target translation

Cytryńska, M., Rahnamaeian, M., Zdybicka-Barabas, A., Dobslaff, K., Züchner, T., Sacheau, G., Innis, C.A., Vilcinskas, A. (2020). Proline-Rich Antimicrobial Peptides in Medicinal Maggots of Lucilia sericata Interact With Bacterial DnaK But Do Not Inhibit Protein Synthesis. Front Pharmacol. 11, 532.

Not all PrAMPs target the ribosome, and this study led by the Vilcinskas lab investigates the activity of two such peptides, Lser-PRP2 and Lser-PRP3, from the larvae of the common green bottle fly. It shows that neither of them block protein synthesis in vitro, but that both bind to the bacterial chaperone DnaK and hence may interfere with protein folding.